Manuscript Number : IJSRSET2183179

Chemistry and biological evaluation of some new 1,2,3,4-tetrahydro-n-(substitutedphenyl)-6-methyl-2-oxo-4-[3-phenyl-1-(pyridine-4-carbonyl)-1h-pyrazol-4-yl]pyrimidine-5-carboxamide

Authors(3) :-Chetan C. Rathod, Manish J. Solanki, Haresh K. Ram

An proficient Synthesis of a novel series of Chemistry and biological evaluation of some new 1,2,3,4-tetrahydro-n-(substitutedphenyl)-6-methyl-2-oxo-4-[3-phenyl-1-(pyridine-4-carbonyl)-1h-pyrazol-4-yl]pyrimidine-5-carboxamide (4a-j) was accomplished from 3-phenyl-1-(pyridin-4-ylcarbonyl)-1-H-pyrazole-4-carbaldehyde, substituted aceto-acetanilide and in acidic medium. and then after the cooling product was obtained. All the recently synthesized compounds were characterized by the Mass, IR, 1H-NMR and mass spectroscopic techniques and by elemental analyses. The newly synthesized compounds were assessed for their antibacterial and antifungal activity.

Authors and Affiliations

Chetan C. Rathod
Department of Chemistry, Shri Jagdishprasad Jhabarmal Tibrewala University in Jhunjhunu, Rajasthan, India
Manish J. Solanki
C. U. Shah Science College Ahmedabad, Gujarat, India
Haresh K. Ram
Department of Chemistry, Tolani College of Arts & Science, Adipur, Gujarat, India

3-phenyl-1-(pyridin-4-ylcarbonyl)-1-H-pyrazole-4-carbaldehyde, urea, substituted aceto- acetanilide, ethanol and conc. HCl.

  1. M. M. Kandeel, S. M. Ali, E. K. A. Abed El Ali, M. A. Abdelgawad, P. F. Lamie, Org Chem Indian J 2013, 9, 81.
  2. C. R. Petrie, H. B. Cottam, P. A. Mckernan, R. K. Robins, G. R. Revankar, J Med Chem 1985, 28, 1010–6.
  3. (a)M. N. Nasr, M. Gineinah, Arch Pharm Res 2002, 335, 195. (b) K. S. Parikh, S. P. Vyas, Pharm Lett 2012a, 4, 638–40.
  4. P. G. Baraldi, M. G. Pavani, M. Nunez, P. Brigidi, B. Vitali, R. Gambari, R. l. Romagnoli, J Med Chem 2002, 10, 449–56. https://doi.org/10.1016/S0968-0896(01)00294-2.
  5. R. V. Antre, A. Cendilkumar, D. Goli, G. S. Andhale, R. J. Oswal, Saudi Pharm J 2011, 19, 233–43. https://doi.org/ 10.1016/j.jsps.2011.05.006.
  6.  S. M. Sondhi, M. Johar, S. Rajvanshi, S. G. Dastidar, R. Shukla, R. Raghubir, J. W. Lown, Aust J Chem 2001, 54, 69. https://doi.org/10.1071/CH00141.
  7. M. S. Chowdhury, M. M. Matin, M. N. Anwar, Chittagong Univ Stud Part II Sci 1997, 21, 79.
  8. K. S. Parikh, S. P. Vyas, Int J Pharm Sci Res 2012c, 3, 3425.
  9. N. P. Singh, A. N. Srivastava, Asian J Chem 2013, 25, 53.
  10. S. Maddila, A. S. Kumar, S. Gorle, M. Singh, P. Lavanya, S. B. Jonnalagadda, Lett Drug Design Discov 2013, 10, 186–93. https://doi.org/10.2174/157018013804725152.
  11.  P. Vicini, A. Geronikaki, M. Incerti, B. Busonera, G. Ooni, C. A. Kabras, P. L. Colla, Biol Med Chem 2003, 11, 4785–9. https://doi.org/10.1016/S0968-0896(03)00493-0.
  12. R. Yerra, K. Naresh, K. N. Jayaveera, Int J PharmTech Res 2012, 4, 648.

Publication Details

Published in : Volume 6 | Issue 3 | May-June 2019
Date of Publication : 2019-05-30
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 427-433
Manuscript Number : IJSRSET2183179
Publisher : Technoscience Academy

Print ISSN : 2395-1990, Online ISSN : 2394-4099

Cite This Article :

Chetan C. Rathod, Manish J. Solanki, Haresh K. Ram, " Chemistry and biological evaluation of some new 1,2,3,4-tetrahydro-n-(substitutedphenyl)-6-methyl-2-oxo-4-[3-phenyl-1-(pyridine-4-carbonyl)-1h-pyrazol-4-yl]pyrimidine-5-carboxamide, International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 6, Issue 3, pp.427-433, May-June-2019. Journal URL : https://res.ijsrset.com/IJSRSET2183179

Article Preview